I've used Hydroxycut and Hoodia pills but they were a different brand (not Hoodia Vex). Hydroxycut suppressed my appetite like crazy but I was also restless 24/7. I had trouble falling asleep and when I finally dozed off, I'd wake up eight hours later still groggy and tired as if I hadn't slept at all. I decided not to continue with them because after two weeks, I was feeling like poo. The hoodia pills were also a no go..they just made me throw up haha